2/27/2023 0 Comments Paulino vargas compositor![]() Target cells moving along the nanotube path were commonly polarized such that their uropods faced the direction of movement. ![]() Functionally, nanotubes could aid the lysis of distant target cells either directly or by moving target cells along the nanotube path into close contact for lysis via a conventional immune synapse. In addition, tyrosine-phosphorylated proteins and Vav-1 accumulated at such junctions. Quantitative live-cell fluorescence imaging suggested that MICA accumulated at small nanotube synapses in sufficient numbers to trigger cell activation. Most importantly, NK cell nanotubes contained a submicron scale junction where proteins accumulated, including DAP10, the signaling adaptor that associates with the activating receptor NKG2D, and MHC class I chain-related protein A (MICA), a cognate ligand for NKG2D, as occurs at close intercellular synapses between NK cells and target cells. The frequency of nanotube formation was dependent on the number of receptor/ligand interactions and increased on NK cell activation. Nanotubes were formed when NK cells contacted target cells and moved apart. Here, we present evidence that nanotubes allow human natural killer (NK) cells to interact functionally with target cells over long distances. Membrane nanotubes are membranous tethers that physically link cell bodies over long distances. Membrane nanotubes facilitate long-distance interactions between natural killer cells and target cellsĬhauveau, Anne Aucher, Anne Eissmann, Philipp Vivier, Eric Davis, Daniel M. ![]()
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